| Exit |
Eastbound (read down) |
Westbound (read up) |
| |
Interstate 78 ends |
| 1A |
 |
Interstate 81 North
Hazelton |
| 1B |
|
Interstate 81 South
Harrisburg
|
| 6 |
|
(Eastbound only) |
| 8 |
|
US-22
Pa-343
Lebanon
Fredericksburg
|
| 10 |
|
Pa-645
Frystown |
| 13 |
|
Pa-501
Bethel |
| 15 |
|
Grimes
|
| 16 |
|
Midway
|
| 17 |
|
Pa-419
Rehrersburg |
| 19 |
|
Pa-183
Strausstown |
| 23 |
|
Shartlesville
|
| 29A |
|
Pa-61
Reading |
| 29B |
|
Pa-61
Pottsville |
| 30 |
|
Hamburg
|
| 35 |
|
Pa-143
Lenhartsville |
| 40 |
|
Pa-737
Kutztown
Krumsville |
| 45 |
|
Pa-863
Lynnport
New Smithville |
| 49A |
|
Pa-100
Trexlertown |
| 49B |
|
Pa-100
Fogelsville
|
| 53 |
|
Pa-309
Pennsylvania Turnpike
Tamaqua
|
| 54A |
|
US-222
Hamilton Boulevard
|
| 54B |
|
US-222
Hamilton Boulevard
|
| 55 |
|
Pa-29
Cedar Crest Boulevard
|
| 57 |
|
Lehigh St
|
| 58 |
|
Emaus Ave South
|
| 59 |
|
(Eastbound exit only) |
| 60A |
|
Pa-309
Quakertown
|
| 60B |
|
Pa-145
South 4th St
|
| 67 |
|
Pa-412
Hellertown
Bethlehem |
| 71 |
|
Pa-33
US-22
Stroudsburg
|
| 75 |
|
Pa-611
Easton
Philadelphia
|
| |
Interstate 78 continue in New Jersey |
