| Exit |
Northbound (read down) |
Southbound (read up) |
| |
Interstate 81 continue in Maryland |
| 1 |
 |
Pa-163
State Line
|
| 3 |
|
US-11
Molly Pitcher Highway
|
| 5 |
|
Pa-16
Waynesboro
Greencastle
|
| 10 |
|
Pa-914
Marion
|
| 14 |
|
Pa-316
Wayne Ave
|
| 16 |
|
US-30
Lincoln Way
|
| 17 |
|
Walker Rd
|
| 20 |
|
Pa-997
Scotland
|
| 24 |
|
Pa-696
Fayette St
|
| 29 |
|
Pa-174
King St
|
| 37 |
|
Pa-233
Newville
|
| 44 |
|
Pa-465
Plainfield
|
| 45 |
|
College St
|
| 47A |
|
Pa-34
Hanover Street
|
| 47B |
|
Pa-34
Hanover Street
|
| 48 |
|
(Northbound exit only) |
| 49 |
|
Pa-641
High St
|
| 52 |
|
US-11
I-76
New Kingstown
Middlesex
Penna Turnpike
|
| 57 |
|
Pa-114
Mechanicsburg
|
| 59 |
|
Pa-581
US-11
Camp Hill
|
| 61 |
|
Pa-944
Wertzville Road
|
| 65 |
|
US-11
US-15
Marysville
Enola
|
| 66 |
|
Front St
Downtown Harrisburg
|
| 67 |
|
  
US-22
US-322
Pa-230
Cameron St
Harrisburg
Lewistown
State College
|
| 69 |
|
Progress Avenue
|
| 70 |
|
US-322
I-83
South Harrisburg
York
|
| 72 |
|
Paxtonia
Linglestown
|
| 77 |
|
Pa-39
Manada Hill
Hershey
|
| 80 |
|
Pa-743
Grantville
Hershey
|
| 85A |
|
(Northbound exit only) |
| 85B |
|
Pa-934
Annville
FT Indiantown Gap
|
| 89 |
to be continued |
| 90 |
| 100 |
| 104 |
| 107 |
| 112 |
| 116 |
| 119 |
| 124 |
| 131 |
| 134 |
| 138 |
| 141 |
| 143 |
| 145 |
| 151 |
| 155 |
| 159 |
| 164 |
| 165 |
| 168 |
| 170 |
| 175 |
| 178 |
| 180 |
| 182 |
| 184 |
| 185 |
| 186 |
| 187 |
| 188 |
| 190 |
| 191 |
| 194 |
| 197 |
| 199 |
| 201 |
| 202 |
| 206 |
| 211 |
| 217 |
| 219 |
| 223 |
| 230 |
| |
Interstate 81 continue in New York |
